Measurement of bisulfite in biologic solutions.

Neutralization of Excess Formalin by sodium Meta - Bisulfite in combined Anthrax & clostridial vaccine

Sodium bisulfite: scapegoat for chloroprocaine neurotoxicity?

BACKGROUND Neurologic deficits after apparent intrathecal injection of 3% Nesacaine-CE intended for epidural administration created concern about the potential toxicity of chloroprocaine and the preservative sodium bisulfite. Although bisulfite-free formulations of chloroprocaine were subsequently introduced into clinical practice, the relative toxicities of this anesthetic and preservative wer...

Reactions of Bisulfite, an Environmental Chemical, with Nucleic Acids and Other Biological Substances

The reactions of bisulfite in aqueous solutions with nucleic acids and their constituents are briefly reviewed. Co-operative actions of bisulfite and certain amines, i.e. semicarbazide, hydrazine, hydroxylamine and methoxyamine, in inducing mutations in bacteriophage lambda are described. Rapid inactivations of lambda during aerobic oxidation of bisulfite was found to be a result of damages in ...

Stabilizers of edaravone aqueous solution and their action mechanisms. 1. Sodium bisulfite

Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) has been used as a free radical scavenging drug for the treatment of acute ischemic stroke in Japan since 2001. Edaravone is given to patients intravenously; therefore, it is distributed in the form of an aqueous solution. However, aqueous solutions of edaravone are very unstable because it is present as edaravone anion, which is capable of transf...

Detection of Cytosine Methylation in Ancient DNA from Five Native American Populations Using Bisulfite Sequencing

While cytosine methylation has been widely studied in extant populations, relatively few studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic marks in ancient DNA have inferred patterns of methylation in highly degraded samples using post-mortem damage to cytosines as a proxy for cytosine methylation levels. However, this approach limits the inference of methyla...